Thiazovivin

SKU: orb1226747

Description

Thiazovivin (Tzv) is a novel ROCK inhibitor with IC50 of 0.5μM, promotes hESC survival after single-cell dissociation.

Key Properties

• CAS Number: 1226056-71-8
• MW: 311.36
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₃N₅OS
• SMILES: O=C(C1=CSC(NC2=NC=NC=C2)=N1)NCC3=CC=CC=C3
• Target: ROCK
• Solubility: DMSO: 15 mg/mL (48.17 mM)

Bioactivity

• In Vitro:
  Thiazovivin (GMP) (0.5 μM, at 1 day) promotes rapid and efficient reprogramming of mouse tail tip and embryonic fibroblasts into iPSCs. Thiazovivin (GMP) enhances the efficiency in reprograming endometrial adult stromal cells to iPSCs. Thiazovivin (GMP) (2 μM) induces iPSCs and induced neural stem cells (iNSCs) from human urine cells (UCs). Thiazovivin (GMP) (2 μM, for the first 24 h) improves growth rate of hiPSCs. Thiazovivin (GMP) (0.5 μM) together with SB431542 and PD0325901 promotes iPSC reprogramming by regulating cell-cell interactions.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tzv

Quick Database Links

Gene Symbol

ROCK