Thalidomide

SKU: orb1310829

Description

Thalidomide is a synthetic glutamic acid derivative with known teratogenic effects. It is widely used in research for its immunomodulatory, anti-inflammatory, and anti-angiogenic properties, applicable in both in vitro and in vivo studies of cancer, autoimmune diseases, and angiogenesis.

Research Area

Immunology & Inflammation, Protein Biochemistry

Key Properties

• CAS Number: 50-35-1
• MW: 258.3
• Purity: >98%
• Formula: C₁₃H₁₀N₂O₄
• SMILES: O=C1N(C2CCC(=O)NC2=O)C(=O)c2ccccc12
• Target: Ubiquitin ligase
• Solubility: Soluble in DMSO (up to 5 mg/ml).

Bioactivity

• Target IC50:
  CRL4CRBN:250 nM (Kd)
• In Vivo:
  Administering 200mg/kg of Thalidomide resulted in the inhibition of vascularization in the corneal region within rabbits, with the inhibition rate ranging from 30% to 51% across three experiments.
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• In Vitro:
  Thalidomide selectively inhibits the production of tumor necrosis factor-alpha (TNF-α) in human monocytes stimulated by lipopolysaccharides and other agonists. Its suppression of TNF-α is mediated through the enhancement of mRNA degradation. Moreover, thalidomide exerts a direct effect on MM cell lines by inducing apoptosis and G1 phase growth arrest, as well as on patient MM cells resistant to melphalan, doxorubicin hydrochloride, and dexamethasone.
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Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sedoval, Thalomid, TNF-α, Thalidomide, Molecular Glues, MolecularGlues, Ligand for E3 Ligase, LigandforE3Ligase, Ligands for E3 Ligase, inhibit, Inhibitor, E3 ligase-recruiting Moiety, Apoptosis, Autophagy

Compound Identifiers

PubChem CID

5426