Thalidomide-NH-CH2-COOH

SKU: orb1940281

Description

Thalidomide-NH-CH2-COOH is a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker.(In Vitro):PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 927670-97-1
• MW: 331.28
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₃N₃O₆
• SMILES: OC(CNc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O
• Target: α7 nAChR
• Solubility: In Vitro: DMSO : 50 mg/mL (150.93 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine | 2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid

Quick Database Links

Gene Symbol

α7 nAChR