Thalidomide-NH-CH2-COOH

SKU: orb1303328

Description

This compound is a synthesized cereblon E3 ligase ligand-linker conjugate, incorporating a thalidomide derivative connected to a glycine linker. It serves as a key component in the development of PROTACs for targeted protein degradation, a strategy widely used in vitro and in vivo for probing disease-related protein functions.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 927670-97-1
• MW: 331.28
• Purity: 99.74% (May vary between batches)
• Formula: C₁₅H₁₃N₃O₆
• SMILES: O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCC(O)=O
• Target: E3 Ligase Ligand-Linker Conjugates,Ligands for E3 Ligase,Apoptosis,Autophagy
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.02 mM);DMSO:42.5 mg/mL (128.29 mM)

Bioactivity

• In Vitro:
  PROTACs are composed of two distinct ligands joined by a linker: one ligand targets an E3 ubiquitin ligase, while the other targets a specific protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade the target proteins.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cereblon, cereblon, CRBN, E3 ligase-recruiting Moiety, (2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine, 2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid, Inhibitor, LigandforE3Ligase, Ligands for E3 Ligase, Ligand for E3 Ligase, inhibit, Thalidomide, Thalidomide NH CH2 COOH, ThalidomideNHCH2COOH, Thalidomide-NH-CH-2-COOH, Thalidomide-NH-CH2-COOH

Compound Identifiers

PubChem CID

58827328