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TGFβRI-IN-7

SKU: orb3028262

Description

TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.

Research Area

Stem Cell & Developmental Biology

Images & Validation

Key Properties

MW472.582
FormulaC27H32N6O2
SMILESCN(C)CCN1C=C(C=N1)C2=CC3=NC=CC(=C3C=C2)OC4=CN(N=C4C5CCOCC5)C6CC6
TargetTGF-beta/Smad

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information