TGFβRII-IN-3

SKU: orb3134209

Description

TGFβRII-IN-3 (Compound 2r) is a selective inhibitor of the TGFβ type II receptor (TGFβ RII) with an IC50 of 4.1 μM. It inhibits TGFβ signaling by promoting protein degradation of TGFβ RII. Additionally, TGFβRI-IN-7 can block the transition from endothelial to mesenchymal states and inhibit cell migration, making it useful for cancer research.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2351149-20-5
• MW: 468.51
• Formula: C₂₇H₂₇F₃N₂O₂
• SMILES: O=C(C=1C=2C(=O)CC(C)(C)CC2NC1C)N(C)CC3=CC=CC(=C3)C4=CC=C(C=C4)C(F)(F)F
• Target: TGF-beta/Smad

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TGF-beta/Smad