TGFβRI-IN-3

SKU: orb1298043

Description

TGFβRI-IN-3 is a potent and highly selective TGFβR1 inhibitor (IC50 = 0.79 nM) with >2000-fold selectivity over MAP4K4. This tool compound is valuable for immuno-oncology research, enabling the study of TGF-β signaling in both cellular assays and in vivo models of cancer and fibrosis.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2763602-67-9
• MW: 465.57
• Purity: 99.85% (May vary between batches)
• Formula: C₂₈H₂₃N₃O₂S
• SMILES: N(C=1C2=C(C=C(C=C2)C3=CC=C(S(C)(=O)=O)C=C3)N=CC1)C=4C=C(N=CC4)C5=CC(C)=CC=C5
• Target: TGF-beta/Smad
• Solubility: DMSO:50 mg/mL (107.4 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.3 mM)

Bioactivity

• In Vitro:
  TGFβRI-IN-3 inhibits TGFβR1 at an IC 50 of 0.79 nM, 2000-fold selectivity for MAP4K4 .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Smad, TGFβR1, TGFβRI IN 3, TGFβRIIN3, TGFβRI-IN-3, TGFb, TGF-b/Smad, TGFbRI-IN-3, TGFbetaRI-IN-3, TGF-β/Smad, TGFβ, TGF-beta, TGFbeta, TGFbeta/Smad

Compound Identifiers

PubChem CID

162640856