TGF-β mAb (1D11.16.8), InVivoPure+

SKU: orb3127236

Description

The 1D11.16.8 antibody (HB-9849TM) is a mouse monoclonal antibody directed against transforming growth factor-beta (TGF-β) isoforms 1, 2, and 3. TGF-β is a multifunctional cytokine involved in the regulation of proliferation and differentiation of various cell types, including epithelial cells, endothelial cells, fibroblasts, neurons, and immune cells such as T lymphocytes and natural killer cells. This antibody is known for its ability to neutralize TGF-β activity, making it a valuable tool in both in vitro and in vivo studies. It has been shown to significantly improve outcomes in models of advanced pancreatic cancer by inhibiting TGF-β, resulting in reduced mortality, weight loss and muscle wasting. The 1D11.16.8 antibody is highly specific and reacts with TGF-β in multiple species, including humans, mice, rats, monkeys, hamsters, dogs and cows. It is commonly used in research applications such as Western blotting, immunohistochemistry, and functional assays to study the role of TGF-β in various biological processes and diseases.

Images & Validation

• Tested Applications: FA, IHC, IHC-P, IP, NeA, WB
• Reactivity: Bovine, Canine, Hamster, Human, Monkey, Mouse, Rat
• Application Notes:
  Recomended Isotype: Mouse IgG1ĸ Isotype Control. Recomended Isotype Catalog: orb2568795

Key Properties

• Antibody Type: Primary Antibody
• Host: Mouse
• Clonality: Monoclonal
• Isotype: m IgG1
• Clone No.: 1D11.16.8
• Immunogen: Animals were immunized with a bovine TGF-beta2
• Target: GFβ; TGFB1; TGFB2; TGFB3
• Purity: ≥ 95 % (CGE, reducing conditions) ≤ 5 % aggregates (analytical SEC) Endotoxin level ≤ 1 EU/mg
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Form/Appearance: Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
• Concentration: ≥ 1 mg/ mL
• Disclaimer: For research use only

Alternative Names

TGF-β; TGFβ; TGFB1; TGFB2; TGFB3; TGF-B1; TGF-B2; TGF-B3; TGF beta 1; TGF beta 2; TGF beta 3; CED; DPD1; LAP; Latency-associated peptide; prepro-transforming growth factor beta-1; regulatory protein; transforming growth factor; transforming growth factor beta; 1D11.16; 1D11.

Quick Database Links

Gene Symbol

GFβ; TGFB1; TGFB2; TGFB3

UniProt

A6QP91, P21214, P18341