TET2 (vPairTM) Antibodies

• Catalog Number: orb131789
• Category: Antibodies
• Description: Rabbit polyclonal to TET2. TET2 antibodies represent a pair of fully characterized antibodies that recognize two different regions of a target protein. The product is developed by Biorbyt to address whether the signal observed truly represents the protein of interest, an often encountered issue in antibody pairs-based assays. The use of a pair of fully characterized vPair antibodies in the same assay can validate signal specificity since vPair antibodies recognize two independent epitopes of the same protein. Different sets of vPair antibodies are developed at Biorbyt to work with specific applications, including antibody pairs arrays, Western blot, IP-Western, ChIP, IHC, and FACS. TET2 is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). 5-hydroxymethylcytosine may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. TET2 plays an important role in myelopoiesis, and defects in TET2 gene have been associated with several myeloproliferative disorders.
• Clonality: Polyclonal
• Species/Host: Rabbit
• Conjugation: Unconjugated
• Reactivity: Human, Mouse
• Concentration: 100 μg/ml BSA
• Buffer/Preservatives: 0.01% NaN3
• Purity: Affinity purification
• Immunogen: C-terminal region of human TET2 or the N-terminal region of mouse TET2
• UniProt ID: Q6N021, Q4JK59
• MW: 224
• Tested applications: ChIP, IP, WB
• Dilution range: WB:1:1000-1:3000
• Application notes: WB: The apparent protein size on WB may be different from the calculated M.W. due to modifications.; ; Experiment Notes: Rabbit polyclonal antibodies were produced by immunizing animals with GST-fusion proteins containing either the C-terminal region of human TET2 or the N-terminal region of mouse.
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Alternative names: anti Methylcytosine dioxygenase TET2 antibody pair
• Research Area: Cancer, Epigenetics
• Note: For research use only