TET2 Antibody, Mouse Monoclonal

SKU: orb66693

Description

Mouse monoclonal to TET2.TET2 is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). 5-hydroxymethylcytosine may influence chromatin structure andrecruit specific factors or may constitute an intermediate component in cytosine demethylation.TET2 plays an important role in myelopoiesis, and defects in TET2 gene have been associated withseveral myeloproliferative disorders.

Research Area

Metabolism Research

Images & Validation

• Tested Applications: IP, WB
• Dilution Range: WB:1:1000-1:5000,IP:1:50-1:100
• Reactivity: Human, Mouse

Key Properties

• Host: Mouse
• Clonality: Monoclonal
• Immunogen: multiple regions of human TET2
• Molecular Weight: 224
• Purity: Ascites
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-TET2 antibody,anti-Methylcytosine dioxygenase TET2 antibody,anti-KIAA1546 antibody

Western blot of total cell extracts from a. human Jurkat, b. mouse thymus, using monoclonal anti-TET2 (orb66693) at RT for 2 h.

IP-Western. Total extracts from mouse thymus were immunoprecipitated with a. anti-TET1 (orb66692), b. anti-TET2 (orb66693), c. anti-TET3 (orb66694); followed by WB with rabbit polyclonal anti-TET2 (orb67234) at RT for 2 h.

Quick Database Links

UniProt

Q6N021