Tecadenoson

SKU: orb1307689

Description

Tecadenoson (CVT-510) is a selective A1 adenosine receptor agonist used in research. It has been investigated in vitro and in vivo for its potential cardioprotective effects, including applications in studies of heart rate regulation and myocardial ischemia.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 204512-90-3
• MW: 337.33
• Purity: 99.76% (May vary between batches)
• Formula: C₁₄H₁₉N₅O₅
• SMILES: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N[C@@H]3CCOC3)ncnc12
• Target: Adenosine Receptor
• Solubility: DMSO:155 mg/mL (459.49 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (14.82 mM)

Bioactivity

• In Vivo:
  Intravenous infusions of Tecadenoson and diltiazem causes nearly equal prolongations of P-R interval In atrial-paced anaesthetized guinea-pigs. Tecadenoson (2, 5, 20 μg/kg i.p.) causes a rapid and sustained dose-dependent decrease in NEFA at doses that do not cause bradycardia. Tecadenoson (50 μg/kg) treatment induces a significant bradycardia (50% decrease in heart rate at 25 min) .
• In Vitro:
  Tecadenoson is approximately 5 fold more potent to prolong the stimulus-to-His bundle (S-H interval), a measure of slowing AV nodal conduction (EC50=41 nM) than to increase coronary conductance (EC50=200 nM) in the atrial-paced isolated heart. Tecadenoson shortens atrial (EC50=73 nM) but not the ventricular monophasic action potentials (MAP). At concentrations of Tecadenoson (40 nM) and diltiazem (1 μM) that induces equal prolongation of S-H interval (～10 ms), diltiazem, but not Tecadenoson, significantly decreases left ventricular developed pressure (LVP) and markedly increases coronary conductance .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, CVT-510, CVT510, CVT 510, AdenosineReceptor, Adenosine Receptor, A1 adenosine receptor, A1, Tecadenoson, P1 receptor

Compound Identifiers

PubChem CID

158795