Tecadenoson

SKU: orb1218502

Description

Tecadenoson is a selective agonist of A1 adenosine receptor.

Key Properties

• CAS Number: 204512-90-3
• MW: 337.33
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₉N₅O₅
• SMILES: OC[C@H]([C@H]([C@H]1O)O)O[C@H]1n1c2ncnc(N[C@H]3COCC3)c2nc1
• Target: Adenosine Receptor
• Solubility: DMSO:155 mg/mL (459.49 mM)

Bioactivity

• In Vivo:
  In atrial-paced anaesthetized guinea-pigs, intravenous infusions of Tecadenoson and diltiazem causes nearly equal prolongations of P-R interval. Tecadenoson (2, 5, 20 μg/kg i.p.) causes a rapid and sustained dose-dependent decrease in NEFA at doses that do not cause bradycardia. Tecadenoson given at 50 μg/kg causes a significant bradycardia (50% decrease in heart rate at 25 min.
• In Vitro:
  In the atrial-paced isolated heart, Tecadenoson is approximately 5 fold more potent to prolong the stimulus-to-His bundle (S-H interval), a measure of slowing AV nodal conduction (EC50 = 41 nM) than to increase coronary conductance (EC50 = 200 nM). At concentrations of Tecadenoson (40 nM) and diltiazem (1 μM) that causes equal prolongation of S-H interval (~10 ms), diltiazem, but not Tecadenoson, significantly reduces left ventricular developed pressure (LVP) and markedly increases coronary conductance. Tecadenoson shortens atrial (EC50 = 73 nM) but not the ventricular monophasic action potentials (MAP).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CVT-510

Quick Database Links

Gene Symbol

Adenosine Receptor