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TCS PIM-1 1

SKU: orb1305889

Description

TCS PIM-1 1 (SC 204330) is a potent and selective ATP-competitive inhibitor of Pim-1 kinase, with an IC50 of 50 nM. It demonstrates high specificity, showing minimal activity against Pim-2 and MEK1/2 (IC50 >20 µM). This inhibitor is a valuable research tool for studying Pim-1's role in cancer and hematopoiesis in both cellular and animal models.

Research Area

Epigenetics & Chromatin, Signal Transduction

Images & Validation

Key Properties

CAS Number491871-58-0
MW367.2
Purity99.64% (May vary between batches)
FormulaC18H11BrN2O2
SMILESOc1ccc(Br)cc1-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
TargetPim
SolubilityDMSO:16.67 mg/mL (45.4 mM)

Bioactivity

Target IC50
Pim1:50 nM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ATP-competitive, Inhibitor, pyridone, inhibit, SC 204330, scaffold, SC204330, SC-204330, TCS PIM 1 1, TCS PIM1 1, TCS PIM-1 1, Pim kinases, Pim1, Pim-1, Pim

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Key Properties

No computed properties available.

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Protocol Information

TCS PIM-1 1 (orb1305889)

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Available Sizes

Select a size below

1 mg
$ 70.00
5 mg
$ 100.00
10 mg
$ 130.00
1 ml x 10 mM (in DMSO)
$ 140.00
25 mg
$ 240.00
50 mg
$ 340.00
100 mg
$ 490.00
200 mg
$ 690.00
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