TCS-PIM-1-4a

SKU: orb1303054

Description

TCS-PIM-1-4a (SMI-4a) is a potent Pim kinase inhibitor that exhibits broad anti-leukemic activity. It induces cell death in diverse myeloid and lymphoid lines (IC50 0.8-40 µM) by activating AMPK to suppress mTORC1 signaling. This mechanism supports its use in vitro for studying hematological malignancies and related pathway interactions.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 327033-36-3
• MW: 273.23
• Purity: 99.89%
• Formula: C₁₁H₆F₃NO₂S
• SMILES: C(=C1SC(=O)NC1=O)C2=CC(C(F)(F)F)=CC=C2
• Target: Pim,Apoptosis
• Solubility: DMSO:55 mg/mL (201.3 mM)

Bioactivity

• Target IC50:
  Pim:0.8-40 μM
• In Vitro:
  One hour inhibitor treatment (0.5 μM) of HEK-293T cultures at the end of a 4 hour 32PO4 incubation period results in nearly complete inhibition of the autophosphorylation of overexpressed Pim-1. Comparing to Inhibitor VI (Cat. No. 526524), Inhibitor V is less reactive towards DYRK1α (20% vs. 68% inhibition with respective inhibitor at 5 μM) and more potent in PC3 human prostate cancer cell killing (IC50 = 17 vs. 48 μM with respective inhibitor).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cell-cycle, Bax, Bak, Apoptosis, arrest, 4E-BP1, mTORC1, inhibit, Inhibitor, Leukemic, SMI-4a, TCSPIM14a, TCS-PIM-1-4a, TCS PIM 1 4a, Pim kinases, Pim1, Pim2, Pim, p27Kip1

Compound Identifiers

PubChem CID

2864586