TCS-OX2-29

SKU: orb1302411

Description

TCS-OX2-29 is a highly selective orexin receptor 2 (OX2R) antagonist with an IC50 of 40 nM, showing over 250-fold selectivity versus the OX1 receptor. This tool compound is valuable for in vitro and in vivo research exploring the physiological roles of orexin signaling in sleep, arousal, and neuropsychiatric disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 372523-75-6
• MW: 397.51
• Purity: 99.81% (May vary between batches)
• Formula: C₂₃H₃₁N₃O₃
• SMILES: COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H](NCc1ccncc1)C(C)(C)C
• Target: OX Receptor
• Solubility: DMSO:9 mg/mL (22.64 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.52 mM)

Bioactivity

• Target IC50:
  OX2 receptor:40 nM
• In Vitro:
  TCS-OX2-29 shows selectivity for ion channels, and transporters (<30% inhibition at 10 μM), which includes G-protein coupled receptors associated with food intake including galanin and neuropeptide Y. TCS-OX2-29 Inhibits orexin A-induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TCS OX2 29, TCS-OX-2-29, TCS-OX2-29, TCSOX229, inhibit, Orexin Receptor (OX Receptor), OXReceptor, OX2, OX Receptor, Hypocretin Receptor, HCRT Receptor, Inhibitor

Compound Identifiers

PubChem CID

10408514