TCS-OX2-29

SKU: orb1221614

Description

TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.

Key Properties

• CAS Number: 372523-75-6
• MW: 397.51
• Purity: >98% (HPLC)
• Formula: C₂₃H₃₁N₃O₃
• SMILES: COC1=C(OC)C=C2CN(CCC2=C1)C(=O)[C@@H](NCC1=CC=NC=C1)C(C)(C)C
• Target: Kinesin
• Solubility: H2O : < 0.1 mg/mL

Bioactivity

• In Vivo:
  TCS-OX2-29 (5-10 mg/kg; intraperitoneal injection; adult male NMRI mice) treatment suppresses conditioned place preference (CPP) acquisition and expression in both na ve and dependent mice significantly. Animal model: 440 adult male NMRI mice (25-30 g). Dosage: 5 mg/kg and 10 mg/kg. Administration: Intraperitoneal injection (Pharmacokinetic study). Result: Suppressed conditioned place preference (CPP) acquisition and expression in both na ve and dependent mice significantly.
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• In Vitro:
  TCS-OX2-29 inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Kinesin