JNK inhibitor IX

SKU: orb1305990

Description

TCS JNK 5a (SC202671) is a potent and selective small-molecule inhibitor of JNK3 (pIC50=6.7) and JNK2 (pIC50=6.5). It is a valuable research tool for studying JNK signaling in cellular models of neurological disorders and has been utilized in both in vitro and in vivo experimental contexts.

Research Area

Cell Biology

Key Properties

• CAS Number: 312917-14-9
• MW: 332.42
• Purity: >98%
• Formula: C₂₀H₁₆N₂OS
• SMILES: O=C(NC1=C(C#N)C2=C(CCCC2)S1)C1=C2C=CC=CC2=CC=C1
• Target: Kinase
• Solubility: Soluble in DMSO (up to 13 mg/ml with warming) or in Ethanol (up to 4 mg/ml with warming)

Bioactivity

• Target IC50:
  JNK3:6.7(pIC50)|JNK2:6.5(pIC50)
• In Vivo:
  In human skin fibroblasts, JNK inhibitor IX was able to mediate the inhibition of the complete dephosphorylation of c-ABL on serine residues by c-Jun amino-terminal kinase, resulting in a significant decrease in caspase-3 activity.
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Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TCS JNK 5a

Compound Identifiers

PubChem CID

766949