SC-202671

SKU: orb1222377

Description

TCS JNK 5a, also called JNK Inhibitor IX , is a selective and potent inhibitor of JNK inhibitor. Exposure of human Jurkat T cells to SC-202671 targeting JNK2 and JNK3, caused apoptotic DNA fragmentation along with G2/M arrest, phosphorylation of Bcl-2, Mcl-1, and Bim, Δψm loss, and activation of Bak and caspase cascade.

Key Properties

• CAS Number: 312917-14-9
• MW: 332.42
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₆N₂OS
• SMILES: C1CCc2c(C1)c(c(s2)NC(=O)c1cccc2ccccc12)C#N
• Target: JNK2| JNK3
• Solubility: DMSO : ≥ 51 mg/mL; 153.42 mM

Bioactivity

• In Vitro:
  TCS JNK 5a is also screened in a panel of more than 30 kinase assays, including Alk5, c-Fms, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, Tie-2 and VegFr2, and is inactive (pIC50<5.0) against all of them.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TCS JNK 5a, TCS-JNK-5a, JNK Inhibitor IX, SC-202671

Quick Database Links

Gene Symbol

JNK2| JNK3