TBOPP

SKU: orb1309027

Description

TBOPP is a selective small molecule inhibitor of DOCK1 with an IC50 of 8.4 µM. It has demonstrated anti-tumor activity in various cancer models, making it a useful research tool for studying DOCK1 signaling in oncology, both in vitro and in vivo.

Key Properties

• CAS Number: 1996629-79-8
• MW: 490.49
• Purity: 99.79% (May vary between batches)
• Formula: C₂₄H₂₁F₃N₂O₄S
• SMILES: FC(F)(F)c1cccc(c1)-c1ccc(cc1)C(=O)Cn1cc(ccc1=O)S(=O)(=O)N1CCCC1
• Target: Others
• Solubility: DMSO:120 mg/mL (244.65 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.16 mM)

Bioactivity

• Target IC50:
  DOCK1 DHR-2 domain:7.1 μM (kd)|DOCK1:8.4 μM
• In Vivo:
  TBOPP treatment suppressed cancer metastasis and growth in vivo in mice.
• In Vitro:
  TBOPP as a selective inhibitor of DOCK1. TBOPP dampened DOCK1-mediated invasion, macropinocytosis, and survival under the condition of glutamine deprivation without impairing the biological functions of the closely related DOCK2 and DOCK5 proteins.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TBOPP, DOCK1, DOCK1 DHR-2 domain, inhibit, Inhibitor

Compound Identifiers

PubChem CID

122508151