TBOPP

SKU: orb1220008

Description

TBOPP is a selective DOCK1 inhibitor (IC50 : 8.4 μM), with anti-tumor activity for broader types of tumors. TBOPP as a selective inhibitor of DOCK1. TBOPP dampened DOCK1-mediated invasion, macropinocytosis, and survival under the condition of glutamine deprivation without impairing the biological functions of the closely related DOCK2 and DOCK5 proteins.TBOPP treatment suppressed cancer metastasis and growth in vivo in mice.

Key Properties

• CAS Number: 1996629-79-8
• MW: 490.49
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₁F₃N₂O₄S
• SMILES: FC(F)(F)c1cccc(c1)-c1ccc(cc1)C(=O)Cn1cc(ccc1=O)S(=O)(=O)N1CCCC1
• Target: DOCK1|DOCK1 DHR-2 domain
• Solubility: DMSO:120 mg/mL (244.65 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Animal model: C57BL/6 mice (6-to 8-week-old) with ex-3LL cells. Dosage: 0.67 mg per mouse. Administration: Administrated on days 0, 1, 3, and 5; for 2 weeks. Result: The lung metastasis was significantly suppressed.
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• In Vitro:
  Cell Viability Assay Cell line: 3LL cells. Concentration: 12.5 μM Incubation time: 3 days. Result: Inhibited cell viability.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DOCK1|DOCK1 DHR-2 domain