TBA-354

SKU: orb1303965

Description

TBA-354 is a small molecule research compound with potent anti-tubercular activity against the reference strain Mycobacterium tuberculosis H37Rv. It serves as a valuable tool for investigating novel therapeutic strategies in tuberculosis research, including both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 1257426-19-9
• MW: 436.34
• Purity: 99.40%
• Formula: C₁₉H₁₅F₃N₄O₅
• SMILES: [O-][N+](=O)c1cn2C[C@@H](COc2n1)OCc1ccc(nc1)-c1ccc(OC(F)(F)F)cc1
• Target: Antibiotic,Antibacterial
• Solubility: DMSO:55 mg/mL (126.05 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (5.73 mM)

Bioactivity

• In Vivo:
  TBA-354 has high bioavailability and a long elimination half-life. In vitro studies suggest a low risk of drug-drug interactions. Low-dose aerosol infection models of acute and chronic murine tuberculosis reveal time- and dose-dependent in vivo bactericidal activity that is at least as potent as that of delamanid and more potent than that of PA-824.
• In Vitro:
  TBA-354 is narrow spectrum and bactericidal in vitro against replicating and nonreplicating Mycobacterium tuberculosis, with potency similar to that of delamanid and greater than that of PA-824. TBA-354 maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and Clinicalal drug-sensitive and drug-resistant isolates. TBA-354 is 5 to 10 times more potent than PA-824, but selected mutants are cross-resistant to PA-824 and delamanid. TBA-354 is 2 to 4 times more potent than PA-824 when combined with bedaquiline, and when administered at a dose equivalent to that of PA-824, TBA-354 demonstrated superior sterilizing efficacy.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Antibacterial, Antibiotic, Bacterial, Inhibitor, inhibit, TBA 354, TBA354, TBA-354

Compound Identifiers

PubChem CID

49836057