Stargazin Antibody (Biotin)

SKU: orb150201

Description

Mouse monoclonal to TARP Gamma2 (Biotin). Stargazin belongs to a group called voltage gated calcium channels (VGCCs) which are present in most excitable cells. Stargazin is thought to stabilize the calcium channel in an inactivated (closed) state. There are five high voltage activated calcium channel types (L, N, P, Q, and R) and one low voltage activated channel type (T). Each of these channels exists as a heteromultimer of a1, b, a2/ d and g subunits with the voltage activated calcium channel function carried by the a subunits. VGCCs exert spatial and temporal control over cellular calcium concentrations and serve to modulate neurotransmitter release, hormone secretion, muscle contraction, electrical activity, cell metabolism and proliferation, gene expression, and neuronal survival..

Research Area

Neuroscience

Images & Validation

• Tested Applications: ICC, IF, WB
• Dilution Range: WB (1:1000), ICC/IF (1:100)
• Reactivity: Human, Mouse, Rat
• Application Notes:
  1 µg/ml was sufficient for detection of TARP Gamma2/4/8 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Key Properties

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2A
• Clone No.: N245/36 (Formerly sold as S245-36)
• Immunogen: Fusion protein amino acids 203-323 (Cytoplasmic C-terminus) of rat TARPGamma2
• Target: Stargazin
• Molecular Weight: 35-55kDa
• Purification: Protein G Purified
• Conjugation: Biotin

Storage & Handling

• Storage: Conjugated antibodies should be stored according to the product label
• Buffer/Preservatives: 136.36mM Ethanolamine, 133.23 mM Chlorides, 9.55mM Phosphates, 9.55mM Sodium Bicarbonate
• Concentration: 1 mg/ml
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CACNG2, Calcium channel voltage dependent gamma subunit 2, CaV gamma 2, Ipr328, MGC123981, MGC138502, MGC138504, Voltage-dependent calcium channel gamma-2 subunit, Neuronal voltage-gated calcium channel gamma-2 subunit, Stargazin, Stg, Stargazer, TARP, TARP gamma-2, Transmembrane AMPAR regulatory protein gamma-2, AW060990, B230105C07Rik, B930041E13Rik, Wag, Waggler

Quick Database Links

Gene Symbol

Stargazin

UniProt

Q71RJ2

NCBI Gene ID

84347

RefSeq (Protein):NP_445803.1