Taprenepag

SKU: orb1223057

Description

Taprenepag, also known as CP-544326, is a potent and selective EP(2) receptor agonist, was successfully evaluated for its ocular hypotensive activity in a clinical study involving patients with primary open angle glaucoma. Taprenepag is the active metabolite of PF-04217329.(In Vitro):Taprenepag (CP-544326) (0.01-1000 nM) increases cAMP levels in HEK293 cells expressing human EP2 (EC50=2.8 nM). Taprenepag has poor corneal permeability in an ex vivo rabbit corneal model.

Key Properties

• CAS Number: 752187-80-7
• MW: 478.52
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₂N₄O₅S
• SMILES: c1cc(cc(c1)OCC(=O)O)CN(Cc1ccc(cc1)n1cccn1)S(=O)(=O)c1cnccc1
• Target: Pim
• Solubility: DMSO : ≥ 31 mg/mL; 64.78 mM

Bioactivity

• In Vitro:
  Taprenepag (CP-544326) (0.01-1000 nM) increases cAMP levels in HEK293 cells expressing human EP2 (EC50 = 2.8 nM). Taprenepag has poor corneal permeability in an ex vivo rabbit corneal model.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CP-544326 | CP544326,Taprenepag, PF-0421732 metabolite

Quick Database Links

Gene Symbol

Pim