Tandospirone

SKU: orb1678989

Description

Tandospirone (SM-3997) is a selective 5-HT1A receptor partial agonist used in neuroscience research for its anxiolytic and antidepressant properties. Studies, including in vivo models like spontaneously hypertensive rats, demonstrate it enhances the anti-fibrotic effects of valsartan, supporting its utility in cardiovascular and psychiatric disorder research.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 87760-53-0
• MW: 383.49
• Purity: 99.94% (May vary between batches)
• Formula: C₂₁H₂₉N₅O₂
• SMILES: O=C1[C@]2([C@]([C@]3(C[C@@]2(CC3)[H])[H])(C(=O)N1CCCCN4CCN(CC4)C=5N=CC=CN5)[H])[H]
• Target: 5-HT Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.22 mM);H2O:< 1 mg/mL (insoluble);DMSO:15 mg/mL (39.11 mM)

Bioactivity

• Target IC50:
  5-HT1A receptor:27 nM (Ki)|brain hippocampal membranes (rat):9.4 nM (Kd)|brain hippocampal membranes (rat):213 fmol/mg (Bmax)
• In Vivo:
  Chronic administration of Tandospirone (0.2 and 1.0 mg/kg/day, but not 2.0 mg/kg/day) was effective in alleviating elevated levels of eLAC in the anterior cingulate cortex (mPFC) due to foot shock stress. After acute administration of Tandospirone (0, 0.1 and 1 mg/kg, intraperitoneally) to rats, a significant reduction in the number of premature responses in a dose-dependent manner was observed, an index used to assess impulsive behavior.
• In Vitro:
  Tandospirone has negligible effects at 5-HT1B receptors, 5-HT uptake sites, β-adrenergic receptors, muscarinic cholinergic receptors, and benzodiazepine receptors. 3H-Tandospirone rapidly binds to rat brain hippocampal membranes and achieves binding in a high-affinity, reversible, and saturating fashion (Kd: 9.4 nM, Bmax: 213 fmol/mg protein).

Storage & Handling

• Storage: keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-HT1A, 5HTReceptor, 5HT Receptor, SM 3997, SM3997, SM-3997, Tandospirone

Compound Identifiers

PubChem CID

91273