Tandospirone citrate

SKU: orb1299843

Description

Tandospirone citrate (SM-3997 citrate) is a selective partial agonist for the 5-HT1A receptor with high affinity (Ki: 27 nM). It is widely used in neuroscience research to investigate serotonin signaling, anxiety, and depression in both in vitro binding assays and in vivo behavioral models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 112457-95-1
• MW: 575.61
• Purity: 99.90%
• Formula: C₂₇H₃₇N₅O₉
• SMILES: OC(=O)CC(O)(CC(O)=O)C(O)=O.[H][C@]12CC[C@]([H])(C1)[C@]1([H])C(=O)N(CCCCN3CCN(CC3)c3ncccn3)C(=O)[C@]21[H]
• Target: 5-HT Receptor
• Solubility: H2O:10.4 mg/mL (18.07 mM);DMSO:50 mg/mL (86.86 mM)

Bioactivity

• Target IC50:
  5-HT1A:27 nM（ki）
• In Vivo:
  Improvements in total abdominal scores were significantly larger with tandospirone than placebo at weeks 1, 2, and 4. Significantly greater improvements in the tandospirone group were observed in upper abdominal pain (P=0.02) and discomfort (P=0.002) at week 4. The proportion of responders was significantly greater in the active treatment arm at weeks 3 (P=0.017) and 4 (P=0.0016). Significant improvements in STAI (P<0.0001) were reported in both arms, as well as in the majority of questions in the SF-8 (P=0.04). No serious adverse events were reported, with similar rates in both study arms
• Cell Research:
  In this double-blind, placebo-controlled, multicenter study, FD patients were randomized to treatment with 10 mg t.i.d. tandospirone citrate or to placebo for 4 weeks. The primary end point was change in abdominal symptom scores. The difference in the proportion of responders (a total abdominal symptom score of 0 or 1) was also assessed. The quality-of-life questionnaire, the SF-8, and a psychological test questionnaire, the State-Trait Anxiety Inventory (STAI), were completed at baseline and at weekly intervals

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, 5-HT, 5HTReceptor, 5-hydroxytryptamine Receptor, 5-HT Receptor, 5HT Receptor, Serotonin Receptor, Tandospirone, Tandospirone Citrate, Tandospirone citrate, SM 3997, SM 3997 Citrate, SM3997, SM-3997, SM3997 Citrate, SM-3997 citrate, SM-3997 Citrate

Compound Identifiers

PubChem CID

60558