Tamsulosin hydrochloride

SKU: orb1310833

Description

Tamsulosin hydrochloride

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 106463-17-6
• MW: 444.97
• Purity: 99.95%
• Formula: C₂₀H₂₉ClN₂O₅S
• SMILES: Cl.CCOc1ccccc1OCCN[C@H](C)Cc1cc(c(OC)cc1)S(=O)(=O)N
• Target: Endogenous Metabolite,Adrenergic Receptor
• Solubility: DMSO:50 mg/mL (112.37 mM);H2O:4.5 mg/mL (10.11 mM)

Bioactivity

• In Vivo:
  Tamsulosin exhibits high plasma-protein binding, largely to α1-acid glycoprotein. It is metabolized, mainly by cytochrome P450 (CYP) 3A4 and CYP2D6 to compounds with low abundance, and 8.7–15% of an oral dose is excreted renally a the parent compound the pharmacokinetics of tamsulosin are not affected to a major extent by age, and pharmacokinetic alterations in renally impaired patients relate largely to an increased concentration of α1-acid glycoprotein. Pharmacokinetic alterations with hepatic impairment are also only moderate, thus neither renal nor mild to moderate hepatic impairment necessitates dose adjustment. Early studies of tamsulosin IR in Experimental animals, such as rats and dogs, showed rapid absorption of tamsulosin after oral administration (within 30–90 minutes) but absolute bioavailability of only 7–23% in rats and 30 42% in dogs the absolute bioavailability of tamsulosin MR in fasted humans is approximately 100% the tmax is typically about 5 hours (reported range of mean Values 2.9-5.6 hours) in the fasted state and about 6 hours in the fed state (range 5.2-7.0 hours). Animal studies involving intravenous injection of radiolabelled tamsulosin and measurement of radiolabel in various tissues after 10 minutes have show the presence o the drug in various tissues, ranked in the following order: kidney>lung≈heart>submaxillary g and>liver ≈spleen≈aorta≈vas deferens> prostate>>cerebral cortex the latter being close to detection limits. Tamsulosin may not pas the blood-brain barrier.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AdrenergicReceptor, Adrenergic Receptor, Flomax hydrochloride, LY 253351, LY253351, LY-253351, α1B-adrenergic receptor, α1D-adrenergic receptor, α1A-adrenergic receptor, Tamsulosin

Compound Identifiers

PubChem CID

5362376