TA-01

SKU: orb1225912

Description

A potent inhibitor of Casein Kinase CK1ε, CK1δ and p38α with IC50 of 6.4, 6.8 and 6.7 nM, respectively; inhibits the phosphorylation of proteins downstream of p38α MAPK such as MAPKAPK2 and HSP27 during cardiogenesis, and increases ATF-2 and MEF2C during cardiac differentiation.

Key Properties

• CAS Number: 1784751-18-3
• MW: 351.3246
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₂F₃N₃
• SMILES: FC1=CC=CC=C1C2=C(C3=CC=NC=C3)NC(C4=C(F)C=CC=C4F)=N2
• Target: Casein Kinase
• Solubility: 10 mM in DMSO

Bioactivity

• In Vitro:
  TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively. TA-01 (5 μM) is not cytotoxic, completely inhibits cardiogenesis, but induces cardiogenesis at lower concentration.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TA01 | TA 01

Quick Database Links

Gene Symbol

Casein Kinase