T56-LIMKi

SKU: orb1222992

Description

T-5601640 is a selective LIM kinase 2 (LIMK2) inhibitor.

Key Properties

• CAS Number: 924473-59-6
• MW: 389.33
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₄F₃N₃O₃
• SMILES: Cc1noc(c1)C(=O)Nc1cccc(c1)C(=O)Nc1cccc(c1)C(F)(F)F
• Target: Histamine Receptor
• Solubility: DMSO : ≥ 36 mg/mL; 92.47 mM

Bioactivity

• In Vivo:
  T56-LIMKi can induce inhibition of cofilin phosphorylation and Panc-1 tumor shrinkage In vivo. Mice treated with T56-LIMKi (60 mg/kg) shows a significant decrease in tumor volume compared to control.
• In Vitro:
  T56-LIMKi efficiently inhibits the growth of ST88-14, U87, Panc-1 cells, A549 lung cancer cells with IC50 values of 18.3, 7.4, 35.2 and 90 μM, respectively. T56-LIMKi decreases phosphorylated cofilin (p-cofilin) levels and thus inhibits growth of several cancerous cell lines, including those of pancreatic cancer, glioma and schwannoma. It blocks the phosphorylation of cofilin which leads to actin severance and inhibition of tumor cell migration, tumor cell growth, and anchorage-independent colony formation in soft agar. T56-LIMKi (10-50 μM) reduces p-cofilin in a dose-dependent manner in NF1/MEFs with an IC50 of 30 μM. Notably, the inhibitor does not affect the amounts of total cofil. 50 μM T56-LIMKi causes a statistically significant reduction in the number of cells exhibiting stress fibers.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

T-5601640 | T 5601640 | T5601640 | T56LIMKi

Quick Database Links

Gene Symbol

Histamine Receptor