SZL P1-41

SKU: orb1225620

Description

A small molecule Skp2 E3 ligase inhibitor that prevents Skp2-Skp1 interaction and Skp2 SCF E3 ligase activity in vitro; specific diminishes E3-ligase activity of Skp2-SCF complex, but not of other F-box SCF complex; inhibits Skp2-mediated p27 ubiquitination, induced endogenous p27 protein expression in prostate cancer cells; exhibits potent antitumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival.

Key Properties

• CAS Number: 222716-34-9
• MW: 420.524
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₄N₂O₃S
• SMILES: O=C1C(C2=NC3=CC=CC=C3S2)=COC4=C(CN5CCCCC5)C(O)=C(CC)C=C14
• Target: E3 Ubiquitin Ligase
• Solubility: 10 mM in DMSO

Bioactivity

• In Vivo:
  SZL P1-41 (40-80 mg/kg; i.p.) displays a potent effect on inhibiting prostate and lung tumor growth in Nude mice bearing A549 and PC3 tumor xenografts.
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• In Vitro:
  SZL P1-41 (5-20 μM; 24 hours) induces endogenous p27 protein expression in PC3 cells and also induced expression of p21, another Skp2 substrate.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SZL-P1-41 | SZL P1 41 | SZLP141 | SKP2 E3 Ligase Inhibitor III

Quick Database Links

Gene Symbol

E3 Ubiquitin Ligase