SYVN1 (M) Antibody, Rabbit Polyclonal

• Catalog Number: orb67250
• Category: Antibodies
• Description: Rabbit polyclonal to SYVN1.E3 ubiquitin-protein ligase synoviolin (SYVN1) is a multi-pass membrane protein that belongs to theHRD1 family. It acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically fromendoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting theirdegradation. SYVN1 protects cells from ER stress-induced apoptosis and protects neurons fromapoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promotingtheir degradation. It sequesters p53/TP53 in the cytoplasm and promotes its degradation, therebynegatively regulating its biological function in transcription, cell cycle regulation and apoptosis.
• Clonality: Polyclonal
• Species/Host: Rabbit
• Conjugation: Unconjugated
• Reactivity: Human
• Buffer/Preservatives: 0.01% NaN3
• Purity: Affinity purification
• Immunogen: middle region of human SYVN1
• UniProt ID: Q86TM6
• MW: 68
• Tested applications: WB
• Dilution range: WB:1:500-1:2000
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Alternative names: anti-SYVN1 antibody,anti-E3 ubiquitinprotein ligas
• Research Area: Epigenetics
• Note: For research use only

Western blot analysis of total cell extracts from human Hela using SYVN1 antibody