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Syndecan-1 Antibody / CD138
Catalog Number: orb2634835
| Catalog Number | orb2634835 |
|---|---|
| Category | Antibodies |
| Description | CD138, also designated syndecan-1, is a member of the syndecan family of four transmembrane spanning proteins capable of binding to heparan sulfate and chondroitin sulfate molecules. The syndecans main functions are to control cell growth and differentiation as well as to maintain cell adhesion and cell migration. Under normal conditions CD138 is predominantly expressed on mature plasma cells and early preB-cells, while other haematolymphoid cells are negative. Various types of epithelial cells are also CD138 positive. Squamous epithelial cells show strong membranous and some cytoplasmic staining, except for the mature superficial squamous epithelial cells which are unstained. Mature mesenchymal and neural tissues are not stained. Among haematolymphoid neoplasms, CD138 is expressed in practically all cases of plasma cell malignancies. Among non-haematolymphoid neoplasms the expression of CD138 is found in various types of carcinoma. |
| Clonality | Monoclonal |
| Species/Host | Mouse |
| Isotype | Mouse IgG1, kappa |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | A portion of amino acids 90-250 was used as the immunogen for the Syndecan-1 antibody. |
| UniProt ID | P18827 |
| Tested applications | IHC-P |
| Dilution range | Immunohistochemistry (FFPE): 1-2ug/ml |
| Application notes | Optimal dilution of the Syndecan-1 antibody should be determined by the researcher. |
| Antibody Type | Primary Antibody |
| Clone Number | SDC1/7180 |
| Formula | 1 mg/ml in 1X PBS; BSA free, sodium azide free |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Hazard Information | This Syndecan-1 antibody is available for research use only. |
| Note | For research use only |
IHC staining of FFPE human tonsil tissue with Syndecan-1 antibody (clone SDC1/7180). HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human tonsil tissue with Syndecan-1 antibody (clone SDC1/7180). HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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