SV119

SKU: orb3173051

Description

SV119 is a selective σ-2 receptor (σ₂ receptor) ligand with a Ki of approximately 5-10 nM. It induces apoptosis in various human cancer cell lines by activating caspase-3 and promoting mitochondrial depolarization. SV119 can enhance the effects of chemotherapeutic agents such as Paclitaxel, improving their cytotoxicity against tumor cells. In mouse xenograft models, SV119 significantly inhibits tumor growth both alone and in combination. SV119 is applicable for research on cancers such as breast, prostate, and pancreatic cancer.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 913815-82-4
• MW: 403.57
• Formula: C₂₃H₃₇N₃O₃
• SMILES: C(CCCCCN)N1[C@@]2(C[C@@H](OC(NC3=C(OC)C=CC(C)=C3)=O)C[C@]1(CCC2)[H])[H]
• Target: Apoptosis,Caspase,Sigma receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Caspase,Sigma receptor