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Catalog Number | orb248127 |
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Category | Antibodies |
Description | Survivin, also called BIRC5, is a protein encoded by the human BIRC5 gene. It is a member of the IAP (inhibitor of apoptosis family. Survivin binds to the active form of Caspase-3 and -7, effector or executioner caspases, preventing them from continuing the apoptosis-signaling cascade. Expression is regulated by p53, a regulator of apoptosis-control genes which interacts with the Survivin gene promoter region to repress its expression at the mRNA and protein level. |
Species/Host | Rabbit |
Clonality | Polyclonal |
Tested applications | WB |
Reactivity | Human |
Isotype | Rabbit IgG |
Immunogen | A recombinant protein fragment from human Survivin was used as the immunogen for this antibody. |
Dilution range | Western blot: 2-5ug/ml |
Purity | Protein A affinity chromatography |
Conjugation | Unconjugated |
Formula | 0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
Hazard Information | This Survivin antibody is available for research use only. |
Entrez | 332 |
Storage | Aliquot the antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles. |
Buffer/Preservatives | 1X PBS, pH 7.4 |
Note | For research use only |
Application notes | Provided assay concentrations are suggestions only, antibody titration may be required for optimal results. |
Expiration Date | 12 months from date of receipt. |
Western blot analysis of human samples using Survivin antibody (primary antibody dilution at: at 2 ug/ml)
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