Substance P

SKU: orb1296757

Description

Substance P

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 33507-63-0
• MW: 1347.63
• Purity: 99.51%
• Formula: C₆₃H₉₈N₁₈O₁₃S
• SMILES: CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O
• Target: Endogenous Metabolite,Neurokinin receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (1.48 mM);DMSO:10 mM

Bioactivity

• In Vitro:
  The process involves the desensitization and resensitization of neuropeptide substance P (SP) through the neurokinin 1 receptor (NK1-R), which may relate to the endocytosis and recycling of NK1-R. Both SP and NK1-R are internalized into clathrin-immunoreactive vesicles and subsequently segregated into distinct compartments. Initially, SP remains intact on the cell surface and in early endosomes but gradually degrades in perinuclear vesicles. SP triggers the clathrin-dependent internalization of NK1-R. Within acidified endosomes, the SP/NK1-R complex disassociates, leading to the degradation of SP while NK1-R is recycled back to the cell surface. This mechanism of SP-induced NK1-R internalization is observed in transfected epithelial cells.

Storage & Handling

• Storage: keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Neurokinin P, Neurokinin Receptor, Neurokinin receptor, Neurokininreceptor, NK receptor, NK1, inhibit, Inhibitor, EndogenousMetabolite, Endogenous Metabolite, Human Endogenous Metabolite, Substance P, Tachykinin receptor

Compound Identifiers

PubChem CID

36511