SU6656

SKU: orb1223149

Description

SU6656 is a potent and selective dual inhibitor of Src family kinases and Aurora kinase. SU6656 modulates CTGF (connective tissue growth factor) expression in an ERK-dependent manner. SU6656 induces caspase-independent cell death in FRO anaplastic thyroid carcinoma cells and therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo.

Key Properties

• CAS Number: 330161-87-0
• MW: 371.45
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₁N₃O₃S
• SMILES: CN(C)S(=O)(=O)c1cc2c(cc1)NC(=O)/C/2=C\c1cc2c([nH]1)CCCC2
• Target: Raf
• Solubility: DMSO : 18.5 mg/mL. 49.80 mM

Bioactivity

• In Vivo:
  Animal model: Swiss albino male mice. Dosage: 2, 4 mg/kg. Administration: Intraperitoneal injection; once. Result: Significantly decreased IPoCo mediated increase in fall down time.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SU6656 | SU 6656 | SU-6656

Quick Database Links

Gene Symbol

Raf