SU6656

SKU: orb1300275

Description

SU 6656 is a potent and selective Src family kinase inhibitor, exhibiting IC50 values of 280 nM for Src, 20 nM for Yes, 130 nM for Lyn, and 170 nM for Fyn. This compound is widely used in biochemical and cellular research to investigate signaling pathways in cancer, bone metabolism, and angiogenesis in both in vitro and in vivo models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 330161-87-0
• MW: 371.45
• Purity: 98.73% (May vary between batches)
• Formula: C₁₉H₂₁N₃O₃S
• SMILES: C(=C1C=2C(NC1=O)=CC=C(S(N(C)C)(=O)=O)C2)C3=CC4=C(N3)CCCC4
• Target: Akt,Src,FAK
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:83.33 mg/mL (224.34 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.38 mM)

Bioactivity

• Target IC50:
  Lyn:130 nM|YES:20 nM|Fyn:170 nM|Src:280 nM
• In Vivo:
  SU 6656 markedly and dose-dependently attenuates mecamylamine-induced experimental nicotine withdrawal syndrome in mice measured in terms of WSS and anxiety score. Once-daily administration of SU 6656 (1.5, 3, and 6 mg/kg, i.p.) markedly and dose-dependently attenuates the naloxone-induced morphine withdrawal syndrome.
• In Vitro:
  In NIH 3T3 cells, SU 6656 inhibits the PDGF-stimulated S-phase induction with IC50 of 0.3-0.4 μM. SU 6656 also inhibits PDGF- and serum-mediated NIH 3T3 cell proliferation, as well as epidermal growth factor and colony-stimulating factor 1-stimulated DNA synthesis in normal and colony-stimulating factor 1 receptor transfected NIH 3T3 cells. SU6656 inhibits PDGF-stimulated c-Myc induction and ERK2 activation. Pretreating Jurkat T-cells with SU 6656 leads to increased VSV-G luciferase activity. SU 6656 impairs TGF-β-mediated upregulation of CTGF mRNA and protein in proximal epithelial HKC-8 cells, and also reduces CTGF expression in cells exposed to autocrine growth factors. SU 6656 interferes with Aurora kinase activity resulting in inhibition of cell division and formation multilobular nuclei.
• Cell Research:
  HKC-8 cells are seeded at different cells densities (10,000 cells/cm2 and 50,000 cells/cm2) and cultured in the presence or absence of SU 6656 for 24 and 48 h. Bright eld pictures of cells are recorded by Olympus CK40 microscope using Leica DC Viewer software.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Focal adhesion kinase, FAK, Fyn, Lyn, inhibit, Akt, Protein kinase B, PTK2, PTK2 protein tyrosine kinase 2, Yes, PKB, Src, SU 6656, SU6656, SU-6656

Compound Identifiers

PubChem CID

5309