STX-478

SKU: orb2278795

Description

STX-478 is a brain-penetrant, selective PI3Kα inhibitor for research use. It demonstrates anticancer activity in preclinical models, inhibiting tumor growth in studies relevant to breast cancer and other solid tumors.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2883540-92-7
• MW: 401.29
• Purity: 99.59% (May vary between batches)
• Formula: C₁₆H₁₂F₅N₅O₂
• SMILES: [C@H](NC(NC=1C=NC(N)=NC1)=O)(C(F)(F)F)C2=C(C)C=3C(O2)=C(F)C=C(F)C3
• Target: PI3K
• Solubility: DMSO:100 mg/mL (249.2 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (12.46 mM)

Bioactivity

• In Vivo:
  In Female BALB/c nude mice (CAL-33 xenograft model), STX-478 (30, 100 mg/kg; oral administration) showed a dose-dependent reduction in tumor volume.
• In Vitro:
  STX-478 ( 0-10,000 nM ; 1 h ) targeted the MCF10A cells ( with the H1047R kinase domain mutation ).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PI3Kα

Compound Identifiers

PubChem CID

166532451