(S)-STX-478

SKU: orb2813885

Description

(S)-STX-478 is the S-enantiomer of the brain-penetrant, orally active PI3Kα inhibitor STX-478. It is a research compound used to study cancers such as breast cancer, demonstrating antitumor activity in both cellular assays and in vivo models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2883540-91-6
• MW: 401.29
• Formula: C₁₆H₁₂F₅N₅O₂
• SMILES: [C@@H](NC(NC=1C=NC(N)=NC1)=O)([C@](F)(F)F)C2=C(C)C=3C(O2)=C(F)C=C(F)C3
• Target: PI3K,Others
• Solubility: DMSO:80 mg/mL (199.36 mM)

Bioactivity

• In Vivo:
  Treatment with STX-478 (100 mg/kg) produced powerful antitumor efficacy against PI3Kα mutant tumors in mice without metabolic dysregulation.
• In Vitro:
  STX-478 is a potent and selective inhibitor of all kinase domain mutant forms of PI3Kα found in cancer, with KD and IC50 values of H1047R and WT PI3Kα = 4.7 nmol/L (KD), respectively. 9.4 nmol/L (IC50) and 70 nmol/L (KD) 131 nmol/L (IC50).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(S)STX478, (S)-STX478

Compound Identifiers

PubChem CID

166531866