STO-609

SKU: orb1304079

Description

STO-609 is a potent, cell-permeable inhibitor specifically targeting CaM-KKα and CaM-KKβ. It is widely used in vitro to study CaM-KK signaling pathways in research areas such as cancer, metabolism, and neuronal function.

Research Area

Cell Biology, Epigenetics & Chromatin, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 52029-86-4
• MW: 314.29
• Purity: 98.80%
• Formula: C₁₉H₁₀N₂O₃
• SMILES: C1=CC=C2C(=C1)N=C3N2C(=O)C4=CC=CC5=C(C=CC3=C54)C(=O)O
• Target: AMPK,Autophagy,CaMK
• Solubility: DMSO:8.6 mg/mL (27.36 mM)

Bioactivity

• Target IC50:
  CaMKKβ:47 nM(Ki)|CaMKKα:0.25 μM(Ki)
• In Vitro:
  STO-609 also inhibits their autophosphorylation activities. STO-609 is highly selective for CaM-KK without any significant effect on the downstream CaM kinases (CaM-KI and -IV), and the IC50 value of the compound against CaM-KII is 10 μg/mL. STO-609 inhibits constitutively active CaM-KKα as well as the wild-type enzyme. In transfected HeLa cells, STO-609 dose-dependently suppresses the Ca2+-induced activation of CaM-KIV. STO-609 (1μg/mL) significantly reduces the endogenous activity of CaM-KK in SH-SY5Y neuroblastoma cells (80%).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

STO 609, STO609, STO-609, Inhibitor, inhibit, CaMK, Calmodulin-dependent kinases, Calmodulin-dependent protein kinases, CaM-KKα, CaM-KKβ, Autophagy, AMPK, AMP-activated protein kinase

Compound Identifiers

PubChem CID

3467590