STK16-IN-1

SKU: orb1307720

Description

STK16-IN-1 is a potent and selective small molecule inhibitor of the STK16 kinase, demonstrating an IC50 of 295 nM. This compound is a valuable chemical probe for investigating STK16's function in cellular signaling, membrane trafficking, and its potential roles in cancer biology through in vitro biochemical and cellular assays.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 1223001-53-3
• MW: 293.3
• Purity: 99.84% (May vary between batches)
• Formula: C₁₇H₁₂FN₃O
• SMILES: Cc1cc(ccc1F)-n1c2c3ccnc3[nH]cc2ccc1=O
• Target: Others,Serine Protease
• Solubility: DMSO:55 mg/mL (187.52 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.82 mM)

Bioactivity

• Target IC50:
  STK16:295 nM
• In Vitro:
  STK16-IN-1 inhibits mTOR kinase (IC50: 5.56 μM). STK16-IN-1 shows potent inhibitory activity against STK16 kinase (IC50=0.295 μM) with excellent selective across the kinome as assessed using the KinomeScanTM profiling assay. STK16-IN-1 treatment causes a reduction in cell number and accumulation of binucleated cells, which can be recapitulated by RNAi knockdown of STK16 in MCF-7 cells. Co-treatment of STK16-IN-1 with chemotherapeutics such as cisplatin, doxorubicin, colchicine and paclitaxel results in a slight potentiation of the anti-proliferative effects of the chemotherapeutics. STK16-IN-1 provides a useful tool compound for further elucidating the biological functions of STK16) .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, STK16, STK16 IN 1, STK16IN1, STK-16-IN-1, STK16-IN-1

Compound Identifiers

PubChem CID

58525066