STK16-IN-1

SKU: orb1219019

Description

STK16-IN-1 is an inhibitor of STK16 kinase (IC50: 295 nM).

Key Properties

• CAS Number: 1223001-53-3
• MW: 293.3
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₂FN₃O
• SMILES: CC1=C(C=CC(=C1)N2C(=O)C=CC3=CN=C4C(=C32)C=CN4)F
• Target: STK16
• Solubility: DMSO:15 mg/mL (51.14 mM; Need ultrasonic and warming)

Bioactivity

• In Vitro:
  STK16-IN-1, which exhibits potent inhibitory activity against STK16 kinase (IC50 = 0.295 μM) with excellent selective across the kinome as assessed using the KinomeScanTM profiling assay. STK16-IN-1 inhibits mTOR kinase with an IC50 of 5.56 μM. In MCF-7 cells, treatment with STK16-IN-1 results in a reduction in cell number and accumulation of binucleated cells, which can be recapitulated by RNAi knockdown of STK16. Co-treatment of STK16-IN-1 with chemotherapeutics such as cisplatin, doxorubicin, colchicine and paclitaxel results in a slight potentiation of the anti-proliferative effects of the chemotherapeutics. STK16-IN-1 provides a useful tool compound for further elucidating the biological functions of STK16).
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

STK16