STING ligand-1

SKU: orb1707813

Description

STING ligand-1 is a potent small molecule agonist of the STING pathway, exhibiting an IC₅₀ of 68 nM against the HAQ variant. It serves as a valuable research tool for investigating STING-mediated immune responses in both cellular assays and animal models of inflammation and oncology.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2365039-41-2
• MW: 523.98
• Purity: 98.83% (May vary between batches)
• Formula: C₂₉H₂₇ClFNO₅
• SMILES: C(C(O)=O)[C@@H]1[C@H](N(C(=O)C=2C1=CC=C(F)C2)C3=CC(Cl)=C(C(C)(C)C)C=C3)C=4C=C5C(=CC4)OCCO5
• Target: STING
• Solubility: DMSO:80 mg/mL (152.68 mM)

Bioactivity

• Target IC50:
  HAQ STING:68 nM
• In Vitro:
  STING ligand-1 exhibits good oral exposure, slow binding kinetics, and functional inhibition of STING-mediated cytokine release .

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HAQ STING, STING ligand 1, STING ligand1, STING ligand-1

Compound Identifiers

PubChem CID

135393515