SR-717

SKU: orb1219802

Description

SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. Antitumor activity.SR-717 displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitated antigen cross-priming. SR-717 also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner.

Key Properties

• CAS Number: 2375421-09-1
• MW: 351.19
• Purity: >98% (HPLC)
• Formula: C₁₅H₈F₂LiN₅O₃
• SMILES: [Li+].[O-]C(=O)c1cc(F)c(F)cc1NC(=O)c1ccc(nn1)-n1ccnc1
• Target: STING
• Solubility: DMSO:14.29 mg/mL (40.69 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Animal model: WT or Stinggt/gt mice. Dosage: 30 mg/kg. Administration: Intraperitoneally; once-per-day for 1 week. Result: Maximally inhibited tumor growth.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

STING