STING-IN-2

SKU: orb1298433

Description

STING-IN-2 (C-170) is a potent, covalent inhibitor effective against both human and mouse STING proteins. It is a valuable research tool for studying STING-mediated signaling in autoinflammatory diseases and has been utilized in both cellular and animal model studies to investigate innate immune pathways.

Research Area

Cell Biology

Key Properties

• CAS Number: 346691-38-1
• MW: 288.3
• Purity: 98.76% (May vary between batches)
• Formula: C₁₅H₁₆N₂O₄
• SMILES: CCCCc1ccc(NC(=O)c2ccc(o2)[N+]([O-])=O)cc1
• Target: STING
• Solubility: DMSO:85 mg/mL (294.83 mM)

Bioactivity

• In Vitro:
  In THP-1 cells, pretreated with STING-IN-2 (C-170; 0.5 μM) and stimulated with cGAMP. STING-IN-2 (C-170) treatment decreases the IFNB1 and TNF mRNA levels, and also reduces the p-TBK1 levels

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ERIS, IFNB1, inhibit, MPYS, Inhibitor, palmitoylation, MITA, C 170, C170, C-170, autoinflammatory, cGAMP, p-TBK1, Stimulator of Interferon Genes, STING, STINGIN2, STING-IN-2, STING IN 2, TMEM173, TNF

Compound Identifiers

PubChem CID

2059265