C-170

SKU: orb1218129

Description

C-170 is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). It can be used for autoinflammatory disease research.

Key Properties

• CAS Number: 346691-38-1
• MW: 288.3
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₆N₂O₄
• SMILES: CCCCC1=CC=C(C=C1)NC(=O)C2=CC=C(O2)[N+](=O)[O-]
• Target: STING
• Solubility: DMSO:10 mM

Bioactivity

• In Vitro:
  THP-1 cells are pretreated with STING-IN-2 (C-170; 0.5 μM) and stimulated with cGAMP. STING-IN-2 (C-170) treatment decreases the IFNB1 and TNF mRNA levels, and also reduces the p-TBK1 levels.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

STING-IN-2

Quick Database Links

Gene Symbol

STING