Stachydrine

SKU: orb1301508

Description

Stachydrine (N,N-Dimethyl-L-proline) is a bioactive alkaloid found in Leonurus heterophyllus and citrus fruits, where it serves as a consumption biomarker. It is investigated for its anti-inflammatory properties, primarily through inhibition of the NF-κB signaling pathway in both cellular and animal models of cardiovascular and inflammatory diseases.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 471-87-4
• MW: 143.18
• Purity: 99.94% (May vary between batches)
• Formula: C₇H₁₃NO₂
• SMILES: C[N+]1(C)CCC[C@H]1C([O-])=O
• Target: NF-κB,Endogenous Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (13.97 mM);H2O:32 mg/mL (223.49 mM);DMSO:26 mg/mL (181.59 mM)

Bioactivity

• In Vitro:
  Various concentrations of stachydrine intervention (10(-6) - 10(-4) mol/L) showed better anti-hypertrophic effect and decreased the number of ROS positive myocardial cell (P<0.05). Meanwhile, intervention of stachydrine significantly suppressed the level of p-IkappaB (ser32) protein in the cytosol and NF-kappaB (p65) protein in the nucleus (P<0.05).
  Read more...
• Cell Research:
  Myocardial cells of neonatal rats were incubated with angiotensin II for 48 hours to establish myocardial cell hypertrophy models. The cell surface area and protein/DNA ratio were detected as index for hypertrophy of myocardial cells. ROS positive myocardial cell were counted by means of flow cytometry, the expression of p-IkappaB (ser32) protein in the cytosol and NF-kappaB (p65) protein in the nucleus were also detected by Western blot.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Endogenous Metabolite, EndogenousMetabolite, NF-κB, NFκB, NFkB, NF-kB, N,N-Dimethyl-L-proline, Methyl hygrate betaine, p65, L-stachydrine, Proline betaine, Stachydrine

Compound Identifiers

PubChem CID

115244