Stachydrine

SKU: orb1220723

Description

Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway. Stachydrine is a biomarker for the consumption of citrus fruits.

Key Properties

• CAS Number: 471-87-4
• MW: 143.18
• Purity: >98% (HPLC)
• Formula: C₇H₁₃NO₂
• SMILES: C[N+]1(C)CCC[C@H]1C([O-])=O
• Target: NF-κB
• Solubility: DMSO:26 mg/mL (181.59 mM);H2O:32 mg/mL (223.49 mM)

Bioactivity

• In Vivo:
  Stachydrine attenuates norepinephrine-induced cardiomyocyte hypertrophy and has potential protective effects against β-adrenergic receptor induced Ca2+ mishandling. Stachydrine treatment reduces the expressions of PERK, CHOP, and caspase-3 in the endoplasmic reticulum stress-related apoptosis pathway.
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• In Vitro:
  Stachydrine can inhibit the NF-κB signal pathway, and this may be related to the mechanism of anti-hypertrophic. Intervention of stachydrine significantly suppresses the level of p-IκB protein in the cytosol and NF-κB protein in the nucleus. Tissue factor mRNA is decreased in stachydrine-treated human umbilical vein endothelial cells. Stachydrine attenuates the decline of human umbilical vein endothelial cells viability and the increase of LDH activity induced by anoxia-reoxygenation. A dose dependent decrease in expression of mRNA, and protein levels are observed in stachydrine-treated human prostate cancer cells (PC-3 and LNcaP).
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Proline betaine | L-stachydrine | Methyl hygrate betaine | NN-Dimethyl-L-proline

Quick Database Links

Gene Symbol

NF-κB