Stabilin-2 mAb (3.1), InVivoPure

SKU: orb3127222

Description

Stabilin-2, also known as Feel2, FEX2, FELE-2, FELL2, is a conserved class H scavenger receptors expressed by sinusoidal endothelial cells (ECs) in the liver, lymph nodes, spleen and bone marrow. Stabilin-2 is the major receptor for hyaluronan; blocking antibodies or genetic ablation of Stabilin-2 inhibits hyaluronan uptake and leads to increased systemic hyaluronan levels. Besides hyaluronan, Stabilin-2 also binds other glycosaminoglycans, including heparin. It is also involved in antisense oligonucleotide pharmacokinetics and nanoparticle uptake, and it controls Von Willebrandt factor–factor VIII complex half-life and immunogenicity. The antibody is suitable material for validation and was used in the following applications: IF; IHC staining of rat, mouse spleen or liver; FACS on stably full length mStab2 transfected HEK293 cells and in in-vivo blocking studies.

Images & Validation

• Reactivity: Mouse
• Application Notes:
  Recomended Isotype: Mouse IgG1ĸ Isotype Control, Recomended Isotype Catalog: orb2568796

Key Properties

• Antibody Type: Primary Antibody
• Host: Mouse
• Clonality: Monoclonal
• Isotype: m IgG1
• Clone No.: 3.1
• Immunogen: Recombinant mouse Stabilin-2 fragment (residues 1-330 of Q8R4U0, fused to mouse IgG2b-Fc)
• Target: Stabilin-2
• Purity: ≥ 90 % (CGE, reducing conditions) ≤ 10 % aggregates (analytical SEC) Endotoxin level ≤ 2 EU/mg
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Form/Appearance: Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
• Concentration: ≥ 0.5 mg/ mL
• Disclaimer: For research use only

Alternative Names

Feel2, Hare, FEX2, FELE-2, FELL2, Stab-2, mStab-2, Stab2 clone 3.1, stabilin-2 clone 3.1, Anti-Mouse Stabilin-2 monoclonal antibody. Anti-Mouse Stabilin-2 clone 3.1, Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2 (FEEL-2)

Quick Database Links

Gene Symbol

Stabilin-2

UniProt

Q8R4UO