ST 271

SKU: orb1223440

Description

ST-271 is tyrphostin tyrosine kinase inhibitor. ST271 reduced intracellular Ca2+ levels and inhibited activation of phospholipase C. Elevation of intracellular Ca2+ regulates agonist-induced activation of phospholipase C and that this contributes to the inhibition of thrombin-induced formation of inositol phosphates by the tyrphostin ST271.

Key Properties

• CAS Number: 106392-48-7
• MW: 272.34
• Purity: >98% (HPLC)
• Formula: C₁₆H₂₀N₂O₂
• SMILES: CC(C)c1cc(cc(c1O)C(C)C)/C=C(\C#N)/C(=O)N
• Target: PTK
• Solubility: DMSO : ≥ 110 mg/mL 403.91 mM

Bioactivity

• In Vitro:
  ST271 partially inhibits peptide phosphorylation in the membrane preparation and in permeabilized platelets. ST271 (100 μM) causes complete inhibition of formation of inositol phosphates induced by FcγRII cross-linking, but also induces a small (< 30%) but significant inhibition of the response to thrombin and U46619.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ST-271 | ST271 | ST 271

Quick Database Links

Gene Symbol

PTK