Sparfloxacin

SKU: orb1309792

Description

Sparfloxacin

Research Area

Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 110871-86-8
• MW: 392.4
• Purity: 99.95% (May vary between batches)
• Formula: C₁₉H₂₂F₂N₄O₃
• SMILES: FC1=C2C(C(=O)C(C(O)=O)=CN2C3CC3)=C(N)C(F)=C1N4C[C@H](C)N[C@H](C)C4
• Target: Topoisomerase|||Antibiotic|||DNA gyrase|||Antibacterial
• Solubility: DMSO:1 mg/mL (2.55 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  Sparfloxacin targets DNA gyrase, inhibiting DNA synthesis. It exhibits potent, broad-spectrum antimicrobial activity, effective against Gram-positive bacteria such as Staphylococcus, Streptococcus, and Enterococcus species (MIC=0.1 to 0.78μg/ml), Gram-negative bacteria including Enterobacteriaceae and Pseudomonas species (MIC=0.0125 to 1.56μg/ml), glucose non-fermenters (MIC=0.025 to 0.78μg/ml), Legionella (MIC=0.0125 to 0.05μg/ml), and anaerobes (MIC=0.2 to 0.78μg/ml).
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• In Vitro:
  Orally administered Sparfloxacin produces favorable therapeutic outcomes in mice with systemic infections caused by Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, and Pseudomonas aeruginosa.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PD131501, PD-131501, PD 131501, inhibit, Inhibitor, CI 978, CI978, CI-978, DNAgyrase, DNA gyrase, AT4140, AT-4140, AT 4140, Antibiotic, Bacterial, Sparfloxacin, Topo II, Topo IV, Zagam

Compound Identifiers

PubChem CID

60464